Low dose of fish oil in osteoarthritis: low effect?

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Low dose of fish oil in osteoarthritis: low effect?

We read with great interest the results of the study from Hill et al, on fatty acids diet (two regimens of fish oils: low and high daily dose) in patients with painful knee osteoarthritis (OA). As reported in the associated editorial letter from Felson et al, this is an impressive work spanning over 2 years, which combines both clinical and MRI data. The authors should be congratulated for the ...

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Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose.

OBJECTIVES To determine whether high-dose fish oil is superior to low-dose supplementation for symptomatic and structural outcomes in knee osteoarthritis (OA). METHODS A randomised, double-blind, multicentre trial enrolled 202 patients with knee OA and regular knee pain. They were randomised 1:1 to high-dose fish oil (4.5 g omega-3 fatty acids) 15 mL/day or (2) low-dose fish oil (blend of fis...

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Low-dose versus high-dose fish oil for pain reduction and function improvement in patients with knee osteoarthritis.

Osteoarthritis (OA) is one of the leading generators of musculoskeletal pain and the main cause of disability. It has been considered an inflammatory disease with low grade inflammation affecting the synovium, cartilage and subchondral bone. To date, there is no disease-modifying OA drug. A few studies have evaluated the efficacy of fish oil in the treatment of OA; nevertheless, the effectivene...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2016

ISSN: 0003-4967,1468-2060

DOI: 10.1136/annrheumdis-2016-209399